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Updated: Feb 17, 2026
Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis
Massimiliano Bonifacio1,2, Roberta Zanotti1,2, Emanuele Guardalben1
1Department of Medicine Section of Hematology University of Verona Azienda Ospedaliera Universitaria Integrata di Verona Verona Italy.
Abstract:
Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized by low MC burden, should prompt investigations for an alternative explanation.
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