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Updated: Feb 17, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
How often is patent foramen ovale an innocent bystander?
Francesco Versaci1, Giampiero Vizzari2, Domenico Sergi1
1Department of Cardiovascular Disease Tor Vergata University of Rome Rome Italy.
Abstract:
Patent foramen ovale (PFO) is a risk factor for cryptogenetic stroke; its closure should be considered in selected patients. It is not always clear whether symptoms (presyncope, paresthesia) apparently due to paradoxical embolism are related with other cardiovascular disorders such as arrhythmias. Flecainide administration for post-PFO-closure supraventricular arrhythmias can unmask a latent undiagnosed Brugada syndrome.
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