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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Patterns of vascular calcification in patients with end-stage renal disease and calcific uremic arteriolopathy

Abhilash Koratala1, Muhannad Leghrouz1, Melinda H Phillips1

  • 1Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Clinical Case Reports
|December 12, 2017
PubMed

Insights

Calcific uremic arteriolopathy (calciphylaxis) is a rare, fatal condition causing skin necrosis in dialysis patients. It is often linked to visible vascular calcification on X-rays, presenting in diverse patterns.

Area of Science:

  • Nephrology
  • Dermatology
  • Radiology

Background:

  • Calcific uremic arteriolopathy (calciphylaxis) is a rare, severe condition.
  • It primarily affects patients with end-stage renal disease.
  • Manifestations include painful skin ischemia and necrosis.

Purpose of the Study:

  • To describe the characteristics of calcific uremic arteriolopathy.
  • To highlight its association with vascular calcification.
  • To review the varied radiographic patterns of calcification.

Main Methods:

  • Review of clinical cases.
  • Analysis of radiographic findings.
  • Correlation of clinical and imaging data.

Main Results:

  • Calciphylaxis presents with skin lesions.
  • Vascular calcification is a common finding.
  • Radiographs show diverse calcification patterns.

Conclusions:

  • Calcific uremic arteriolopathy is a critical complication in renal disease.
  • Radiographic evidence of vascular calcification is important for diagnosis.
  • Understanding calcification patterns may aid management.

Keywords:
Calcificationcalciphylaxisend‐stage renal disease

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