Related Experiment Video
Updated: Feb 17, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
1.2K
Intensive Care in a Patient with Toxic Epidermal Necrolysis
J Wallenborn1,2, M Fischer3,4
1Department of Anesthesiology and Intensive Care Medicine, HELIOS Klinikum Aue, Gartenstraße 6, 08280 Aue, Germany.
Case Reports in Critical Care
|December 12, 2017
Summary
Toxic epidermal necrolysis (TEN) is a severe drug reaction. Infliximab effectively halted TEN progression in a severe case, despite complications, highlighting its potential in intensive care settings.
Area of Science:
- Dermatology
- Pharmacology
- Intensive Care Medicine
Background:
- Toxic epidermal necrolysis (TEN) is a life-threatening drug reaction requiring intensive care.
- Prompt diagnosis and management are crucial for patient outcomes.
Observation:
- A 44-year-old male developed TEN after taking allopurinol, ibuprofen, and etoricoxib.
- Initial prednisolone therapy failed to halt disease progression affecting 80% of body surface area.
- Infliximab administration halted further TEN progression.
Findings:
- Infliximab, administered as a single dose, demonstrated efficacy in arresting the advancement of severe TEN.
- The patient experienced prolonged intensive care unit (ICU) stay due to complications including analgosedation, kidney failure, and multi-resistant bacteria colonization.
- Despite complications, the patient recovered and was discharged after four weeks.
Implications:
- Infliximab shows promise as a treatment for rapidly progressing cases of TEN.
- Managing TEN patients in intensive care necessitates careful attention to pain management, positioning, and infection control.
- This case underscores the complex, multidisciplinary approach required for successful TEN treatment and recovery.
Related Concept Videos
01:14Prevention of Further Absorption of Poison
1.3K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
01:22Burn Injuries
4.7K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.7K
01:30Drug Toxicity: Allergic Reactions
16
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
16
01:29Acute Respiratory Failure-V
521
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
521
01:22Acute Kidney Injury VI: Nursing Management
518
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
518
01:26Pharmaceutical Poisoning: Treatment Strategies
17
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
17