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Hepatitis E: A Literature Review.
Juliana Ayres de Alencar Arrais Guerra1, Katia Cristina Kampa1, Daphne Gonçalves Benatti Morsoletto1
1Nossa Senhora das Graças Hospital, Alcides Munhoz Street, 433 - Mercês, Curitiba - PR, Brazil.
Journal of Clinical and Translational Hepatology
|December 12, 2017
Summary
Hepatitis E virus (HEV) infection is rising in Western countries and can cause liver issues. Chronic HEV is a concern for transplant recipients and requires treatment.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Hepatitis E is the fifth known viral hepatitis, with increasing incidence in Western countries.
- Hepatitis E virus (HEV) infection can lead to acute illness, liver failure, chronic hepatitis, and cirrhosis.
- HEV genotypes 1-8 exist, with four commonly affecting humans; genotype 3 is linked to extra-hepatic manifestations.
Purpose of the Study:
- To review the literature on Hepatitis E.
- To explore the relationship between chronic Hepatitis E and transplantation.
Main Methods:
- Literature review of Hepatitis E.
- Analysis of HEV infection in immunocompromised patients, particularly transplant recipients.
Main Results:
- Chronic Hepatitis E develops particularly in transplant recipients, those with hematological malignancies, or HIV-infected individuals.
- Diagnosis can be challenging due to limited test availability and suboptimal sensitivity/specificity.
- Acute Hepatitis E typically does not require treatment, whereas chronic Hepatitis E necessitates intervention.
Conclusions:
- Chronic Hepatitis E is a significant concern in immunocompromised populations, especially transplant recipients.
- Effective management strategies are crucial for chronic Hepatitis E cases.
- Further research is needed to improve diagnostic accuracy and treatment efficacy for Hepatitis E.
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