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Supplemental oxygen therapy does not affect the systemic inflammatory response to acute myocardial infarction

R Hofmann1, P Tornvall1, N Witt1

  • 1Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.

Journal of Internal Medicine
|December 12, 2017
PubMed
Abstract

Insights

Supplemental oxygen did not alter the inflammatory response in patients with acute myocardial infarction (AMI). This study found no significant difference in inflammatory biomarkers between AMI patients receiving oxygen versus ambient air.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation research

Background:

  • Routine oxygen therapy in normoxemic acute myocardial infarction (AMI) patients lacks strong evidence.
  • AMI triggers a systemic inflammatory response.
  • Oxygen therapy's potential to potentiate AMI-induced inflammation was investigated.

Purpose of the Study:

  • To evaluate the impact of oxygen therapy on the systemic inflammatory response in patients with acute myocardial infarction (AMI).
  • To analyze early inflammatory biomarker changes in normoxemic AMI patients receiving oxygen versus ambient air.

Main Methods:

  • Subgroup analysis of the DETO2X-AMI multicentre trial.
  • Randomized controlled trial comparing oxygen (6 L/min for 6-12 h) versus ambient air in suspected AMI patients.
  • Analysis of 92 inflammatory biomarkers using proximity extension assay in 144 confirmed AMI patients.

Main Results:

  • No significant difference in the early release of systemic inflammatory markers between oxygen and air groups.
  • Plasma troponin T levels and inflammatory biomarker changes were similar in both treatment groups.
  • Adjustments for troponin T, age, and sex did not alter the inflammatory marker similarity.

Conclusions:

  • Supplemental oxygen therapy showed no significant impact on the early systemic inflammatory response in normoxemic AMI patients.
  • The findings do not support routine oxygen use for modulating inflammation in AMI.
  • Further research may be needed to clarify oxygen's role in specific AMI subgroups.
Keywords:
acute myocardial infarctionbiomarkercytokineinflammationreactive oxygen species

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