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Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

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Published on: April 11, 2025

Peptide Integrated Optics.

Amir Handelman¹, Nadezda Lapshina², Boris Apter¹

¹Faculty of Engineering, Holon Institute of Technology, 52 Golomb, 5810201, Holon, Israel.

Advanced Materials (Deerfield Beach, Fla.)

|December 12, 2017

Summary

This summary is machine-generated.

Researchers developed novel peptide-based optical materials for integrated bio-optics. These materials enable active waveguiding and offer potential for advanced lab-on-biochips in medical diagnosis and therapy.

Keywords:

passive and active peptide optical waveguides peptide planar wafers peptide-integrated optics reconformation of peptide secondary structures switching of waveguiding regimes

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Area of Science:

Bio-nanophotonics
Integrated bio-optics
Biomedical optical chips

Background:

Silk fibers and synthetic polymers are traditional light-guiding components in bio-optics.
Existing materials have limitations in advanced integrated optical circuit fabrication.

Purpose of the Study:

To propose an advanced concept of integrated bio-optics using bioinspired peptide optical materials.
To develop novel peptide-based materials with desirable optical and biocompatible properties.

Main Methods:

Fabrication of large-area peptide planar wafers using controlled deposition.
Utilized focus ion beam lithography for direct fabrication of peptide optical integrated circuits.
Investigated peptide secondary structure reconformation and its impact on optical properties.

Main Results:

Achieved wide optical transparency, nonlinear, and electrooptical properties in peptide materials.
Observed a modification of optical properties, including visible fluorescence, upon β-sheet architecture formation.
Demonstrated a transition from passive to active optical waveguiding.
Confirmed original biocompatibility and switchable waveguiding regimes.

Conclusions:

New peptide planar optical materials exhibit multifunctional nonlinear optical properties.
These materials are attractive for lab-on-biochip technology, integrating photonic and electronic circuits.
Potential applications include medical diagnosis, light-activated therapy, and health monitoring.