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Evaluation of Hepcidin and Atherosclerosis in Dialysis Patients

Victor Manolov, Julia Petrova, Boris Bogov

    Clinical Laboratory
    |December 12, 2017
    PubMed

    Insights

    Chronic kidney disease (CKD) is linked to cardiovascular disease (CVD) risk factors like elevated hepcidin and homocysteine. Early evaluation of hepcidin and atherosclerosis is crucial for managing CVD risk in CKD patients.

    Area of Science:

    • Nephrology
    • Cardiology
    • Biochemistry

    Background:

    • Chronic kidney disease (CKD) affects 10-15% of the global population, increasing cardiovascular disease (CVD) risk.
    • CKD is a significant cause of morbidity and mortality worldwide, exacerbated by aging populations and comorbidities like diabetes and hypertension.

    Purpose of the Study:

    • To investigate the relationship between CKD, CVD risk factors, and atherosclerosis.
    • To evaluate serum levels of hepcidin, homocysteine, and hsCRP in CKD patients undergoing dialysis.

    Main Methods:

    • Compared 63 CKD patients on chronic dialysis with 63 age-matched controls.
    • Measured CBC, serum iron, ferritin, soluble transferrin receptors, hsCRP, hepcidin, and homocysteine.
    • Assessed intima-media thickness (IMT) as a measure of atherosclerosis.

    Main Results:

    • CKD patients exhibited significantly higher serum hepcidin, homocysteine, and hsCRP levels compared to controls.
    • A strong positive correlation was found between serum hepcidin and homocysteine (r=0.879, p<0.001).
    • IMT positively correlated with hepcidin and homocysteine levels in CKD patients (r=0.788 and r=0.841, respectively).

    Conclusions:

    • CKD is associated with CVD risk factors and may be an independent CVD risk factor.
    • Increased CVD morbidity is observed even in early stages of kidney injury.
    • Early assessment of hepcidin and atherosclerosis is vital for clinical practice in CKD management.
    Abstract

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