Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

939
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
939
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

671
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
671
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

463
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
463

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Midlife Measures of General Cognitive Performance in the National Longitudinal Study of Adolescent to Adult Health (Add Health).

medRxiv : the preprint server for health sciences·2026
Same author

Obtaining comparable measurement of midlife cognitive functioning from disparate cognitive tasks.

Neuropsychology·2026
Same author

Attending an Historically Black College or University and all-cause mortality in US Black adults.

American journal of epidemiology·2026
Same author

Plasma phosphorylated tau 181, vascular risk factors, and cognition in elderly Hispanics.

Journal of Alzheimer's disease : JAD·2026
Same author

Associations between parental history of dementia and plasma markers of inflammation in a multi-ethnic middle-aged community of adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality.

Neurology·2026

Related Experiment Video

Updated: Feb 17, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

11.1K

Assessing cognitive functioning in individuals with cocaine use disorder.

Kirsten M Frazer1,2,3, Jennifer J Manly4, Geraldine Downey1

  • 1a Department of Psychology , Columbia University , New York , NY , USA.

Journal of Clinical and Experimental Neuropsychology
|December 12, 2017
PubMed
Summary

Regular cocaine use may impact cognitive flexibility and language skills, though overall cognitive function remains within normal ranges compared to controls. Further research is needed to fully understand these effects.

Keywords:
Addictioncocainecognitionimpairmentnormative scores

More Related Videos

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.0K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K

Related Experiment Videos

Last Updated: Feb 17, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

11.1K
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.0K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Medicine

Background:

  • Mixed findings exist regarding the cognitive effects of regular cocaine use.
  • Cocaine use disorder (CUD) can impact various cognitive domains.
  • Understanding these impacts is crucial for treatment and recovery.

Purpose of the Study:

  • To compare cognitive functioning in individuals with CUD against non-drug users and marijuana users.
  • To assess performance across six cognitive domains: executive function, attention, episodic memory, working memory, processing speed, and language.
  • To determine if cocaine use disorder is associated with significant cognitive deficits.

Main Methods:

  • A comprehensive cognitive battery, the NIH Toolbox Cognition Battery, was administered.
  • Participants included individuals with CUD (N=20), non-drug users (control), and marijuana users (control).
  • Cognitive scores were compared between groups and against a normative database.

Main Results:

  • All groups scored within the normal range on most cognitive tests.
  • Individuals with CUD performed significantly lower on cognitive flexibility and language tasks compared to marijuana users.
  • No significant differences were observed between CUD group and non-drug users on most measures.

Conclusions:

  • Cognitive functioning in individuals with CUD is largely comparable to controls, falling within normal ranges.
  • Specific deficits in cognitive flexibility and language may be associated with cocaine use disorder.
  • Further investigation is warranted to elucidate the nuanced cognitive effects of CUD.