Adjuvant treatment of node-negative breast cancer

About half of all breast cancer patients do not have axillary nodal involvement at the time of diagnosis, and this fraction will become even larger as more women participate in screening mammography programs. Recently completed trails of limited surgery have changed the primary management of node-negative disease for many women. Now, early results from a number of carefully controlled clinical trails suggest ways in which the approach to adjuvant treatment of this disease can be improved.