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Intraoral Pleomorphic Adenoma in Young Patients
Violante Lina Assunção Alves1, Maria Eduarda Pérez-de-Oliveira1, Jurema Freire Lisboa de Castro1
1Oral Pathology Unit.
Insights
Intraoral pleomorphic adenoma (PA) is rare in young patients. This study describes 4 pediatric cases, highlighting PAs as a consideration for oral submucosal nodules.
Area of Science:
- Oral Pathology
- Pediatric Oncology
- Surgical Pathology
Background:
- Intraoral pleomorphic adenoma (PA) is uncommon in pediatric patients.
- Previous reports on pediatric intraoral PA are limited to single cases or small series.
Purpose of the Study:
- To detail the clinicopathological characteristics of intraoral pleomorphic adenoma in 4 patients under 18 years old.
- To aid in the differential diagnosis of pediatric intraoral submucosal nodules.
Main Methods:
- Retrospective review of intraoral PA cases diagnosed in patients ≤18 years old between 2000 and 2015.
- Clinical data extraction from patient charts.
- Histopathological analysis of H&E stained slides for diagnosis confirmation.
Main Results:
- Four cases of intraoral PA were identified in male patients with a mean age of 16.7 years.
- PAs presented as painless, smooth, well-circumscribed submucosal nodules, primarily on the palate (3 cases) and upper lip (1 case).
- Surgical excision and histopathological examination confirmed ductal arrangements within a fibromyxoid stroma; no recurrence was noted in 3 patients after a mean 30-month follow-up.
Conclusions:
- Pleomorphic adenomas, though rare, should be included in the differential diagnosis for oral submucosal nodules in pediatric patients.
- This study contributes to the understanding of intraoral PA in a young demographic.
Background:
Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series reported previously.
Aim:
The aim of this study was to describe the clinicopathological features of PA in 4 patients under 18 years of age, and to discuss the differential diagnosis of pediatric patients presenting with intraoral submucosal nodules.
Methods:
Between 2000 and 2015, all patients of intraoral PA in patients aged ≤18 years diagnosed in the Oral Pathology Laboratory of the Universidade Federal de Pernambuco, Brazil, were retrieved for the study. Clinical data were recorded from the clinical charts. Histopathological slides stained with hematoxylin and eosin were reviewed to confirm the diagnosis.
Results:
There were 4 cases of PA in patients aged ≤18 years. All patients in this patient series were males, with a mean age of 16.7 years. Three cases occurred in the palate, and in 1 case, the upper lip was affected. All PAs appeared as a painless, smooth surface, well-circumscribed, and submucosal nodule. All patients were surgically excised and subsequent histopathological analysis revealed well-circumscribed tumors composed of cells that were arranged in ducts within a fibromyxoid stroma. No signs of recurrence were observed in 3 patients after a mean follow-up of 30 months. One patient is lost to follow-up.
Conclusion:
Although PAs are unusual in young patients, they should be considered in the differential diagnosis of oral submucosal nodules.
