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Related Experiment Videos

Toxicity studies with quinine hydrochloride.

J C Colley1, J A Edwards, R Heywood

  • 1Huntingdon Research Centre, Cambs, U.K.

Toxicology
|February 1, 1989
PubMed
Summary

Quinine hydrochloride is safe for adults at a daily intake of 40 mg. Studies in rats showed no teratogenic effects or auditory interference, even at high doses.

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Area of Science:

  • Pharmacology and Toxicology
  • Reproductive Toxicology
  • Ototoxicology

Background:

  • Quinine hydrochloride is a medication with a history of use, necessitating updated safety assessments.
  • Understanding the safety profile of quinine hydrochloride is crucial for establishing appropriate dosage guidelines.

Purpose of the Study:

  • To evaluate the safety of quinine hydrochloride through subchronic toxicity studies in rats.
  • To specifically assess the potential for embryo-toxicity and ototoxicity associated with quinine hydrochloride exposure.

Main Methods:

  • Conducted three-month toxicity studies in rats.
  • Performed a dedicated rat embryo-toxicity study.
  • Carried out a specific study to investigate potential ototoxicity.

Main Results:

  • Established an acceptable daily intake (ADI) of 40 mg for adult humans.
  • Observed no teratogenic effects in the embryo-toxicity study.
  • Found no evidence of auditory function interference in rats up to 200 mg/kg.

Conclusions:

  • The established ADI of 40 mg quinine hydrochloride is considered safe for adults.
  • Quinine hydrochloride does not appear to pose a risk for teratogenic effects or ototoxicity at relevant exposure levels.

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