In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of
J M Méndez-Arriaga1, I Oyarzabal2, G Escolano3
1Departamento de Química Inorgánica, Universidad de Granada, Avda. Fuentenueva, 18071 Granada, Spain; Departamento de Parasitología, Universidad de Granada, Avda. Fuentenueva, 18071 Granada, Spain.
Abstract:
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu2(μ-7atp)4Cl2]Cl2·4H2O (1) and [Cu2(μ-7atp)4(H2O)2](NO3)4·H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of -91.2 and -96.1cm-1 respectively. It must be highlighted that the antiparasitic activity of these new complexes has been studied in vitro against three different strains of leishmania spp. and Trypanosoma cruzi, showing a higher efficacy than the 7atp ligand and the reference commercial drugs.
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