Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertension in autoimmune rheumatic diseases: a position paper from the European Society of Hypertension working group on small arteries. Part A: pathophysiology, prevalence and cardiovascular risk estimation.

Journal of hypertension·2026
Same author

Hypertension in autoimmune rheumatic diseases - a position paper from the European Society of Hypertension working group on small arteries. Part B: Recommendations for the clinical management of hypertension.

Journal of hypertension·2026
Same author

BET-induced metabolic reprogramming fuels inflammation at the vascular-fat interface in mice and patients with cardiometabolic disease.

Cell reports·2026
Same author

The cardiometabolic grey zone in young adults: clinical thresholds, cumulative exposure, and long-term cardiovascular risk.

European journal of preventive cardiology·2026
Same author

Ileus causing STEMI electrocardiographic findings.

BMJ case reports·2026
Same author

Cutting out the unnecessary: deprescribing antihypertensive treatments in patients at low cardiovascular risk.

European journal of preventive cardiology·2026

Related Experiment Video

Updated: Feb 17, 2026

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
12:48

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

Published on: September 12, 2015

10.2K

New Methods to Study the Microcirculation.

Damiano Rizzoni1,2, Claudia Agabiti Rosei1, Carolina De Ciuceis1

  • 1Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

American Journal of Hypertension
|December 12, 2017
PubMed
Summary
This summary is machine-generated.

Essential hypertension alters microvessels, increasing media-to-lumen ratio and reducing capillary density. Adaptive optics offers a noninvasive method to assess these retinal arteriolar changes, correlating well with invasive measurements.

Keywords:
adaptive opticsblood pressurehypertensionmicrocirculationretinaretinal arteriolessmall arteries

More Related Videos

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart
07:16

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart

Published on: July 29, 2020

6.2K
Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.7K

Related Experiment Videos

Last Updated: Feb 17, 2026

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
12:48

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

Published on: September 12, 2015

10.2K
Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart
07:16

Dynamic Measurement and Imaging of Capillaries, Arterioles, and Pericytes in Mouse Heart

Published on: July 29, 2020

6.2K
Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.7K

Area of Science:

  • Ophthalmology
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Essential hypertension is linked to microvascular structural changes, including increased media-to-lumen ratio (MLR) in small arteries and reduced capillary density.
  • Assessing microvascular morphology in humans is challenging, with invasive micromyography being the gold standard but having limitations.

Purpose of the Study:

  • To evaluate noninvasive techniques for assessing microvascular morphology in retinal arterioles.
  • To compare adaptive optics (AO) with scanning laser Doppler flowmetry (SLDF) for estimating wall-to-lumen ratio (WLR) and its correlation with invasive MLR measurements.

Main Methods:

  • Utilized adaptive optics (AO) and scanning laser Doppler flowmetry (SLDF) to estimate wall-to-lumen ratio (WLR) in retinal arterioles.
  • Compared noninvasive WLR measurements with invasive media-to-lumen ratio (MLR) from subcutaneous small arteries.

Main Results:

  • Adaptive optics (AO) demonstrated a substantial advantage over SLDF in evaluating microvascular morphology.
  • WLR measured by AO showed a closer correlation with the MLR of subcutaneous small arteries compared to SLDF.

Conclusions:

  • Adaptive optics provides a reliable, noninvasive method for assessing microvascular morphology in clinical settings.
  • This advancement may overcome the limitations of invasive procedures like micromyography for evaluating hypertension-related microvascular changes.