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Related Experiment Video

Updated: Feb 17, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Published on: January 7, 2019

Genotype-Specific Measles Transmissibility: A Branching Process Analysis.

Sarah F Ackley^1,2, Jill K Hacker³, Wayne T A Enanoria²

¹Francis I. Proctor Foundation, University of California, San Francisco.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|December 12, 2017

Summary

Measles genotype B3 is significantly more transmissible than other strains, impacting outbreak size and control strategies. Understanding genotype-specific transmission is crucial for effective measles elimination efforts.

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Last Updated: Feb 17, 2026

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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Published on: October 7, 2011

Area of Science:

Epidemiology
Virology
Public Health

Background:

Measles outbreak sizes exhibit significant heterogeneity, potentially linked to genotype-specific transmissibility.
Postelimination measles surveillance in California (2000-2015) provides data for transmission analysis.

Purpose of the Study:

To characterize differences in measles transmission by estimating the association between genotype and the reproduction number (R).
To analyze measles transmission dynamics using branching process analysis.

Main Methods:

A branching process model was fitted to measles outbreak size distribution using maximum likelihood.
A negative binomial secondary case distribution was assumed.
The reproduction number (R) was estimated for a multigenotype model.

Main Results:

Measles genotype B3 demonstrated significantly higher transmissibility (R=0.64) compared to other genotypes (R=0.43).
This finding remained robust after excluding a major outbreak and using random effects modeling.
Transmission differences were not explained by season, index case age, or vaccination status.

Conclusions:

Variability in measles transmissibility across genotypes has implications for public health control measures.
The vaccination threshold for measles elimination may differ based on genotype and age groups.