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An explanation for the decrease in cell lysis in a rotating tube with increasing ultrasound intensity.

M W Miller1, C C Church, A A Brayman

  • 1Department of Biophysics, School of Medicine and Dentistry, University of Rochester, NY 14642.

Ultrasound in Medicine & Biology
|January 1, 1989
PubMed
Summary
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High ultrasound intensity can decrease mammalian cell lysis by creating a bubble cloud that blocks acoustic transmission. This finding explains the observed reduction in cell damage during in vitro ultrasound exposure.

Area of Science:

  • Acoustic cavitation
  • Cell biology
  • Ultrasound applications

Background:

  • Mammalian cell lysis via ultrasound exposure initially increases then decreases with higher intensities.
  • The mechanism behind reduced cell lysis at high ultrasound intensities is not fully understood.

Purpose of the Study:

  • To investigate the cause of reduced cell lysis at higher ultrasound intensities.
  • To support the hypothesis that bubble clouds mitigate acoustic transmission.

Main Methods:

  • Insonation of in vitro mammalian cells in rotating test tubes.
  • Observation of cell lysis at varying ultrasound intensities.
  • Analysis of acoustic transmission through the fluid medium.

Main Results:

Related Experiment Videos

  • Cell lysis increased to a maximum and subsequently decreased with increasing ultrasound intensity.
  • Acoustically induced "cloud" of bubbles formed in the fluid.
  • This bubble cloud was found to mitigate acoustic transmission, reducing cell lysis.

Conclusions:

  • The reduction in cell lysis at high ultrasound intensities is attributed to the formation of an ultrasonically induced bubble cloud.
  • This bubble cloud acts as a barrier, decreasing acoustic energy transmission and thereby protecting cells from lysis.