Acute Kidney Injury in Children

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Updated: Feb 17, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

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Scott M Sutherland1, David M Kwiatkowski1

  • 1Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA; and Division of Cardiology, Department of Pediatrics, Stanford University, Palo Alto, CA.

Advances in Chronic Kidney Disease
|December 13, 2017
PubMed

Insights

Pediatric acute kidney injury (AKI) is increasingly common in hospitalized children. Improved definitions and diagnostics, including urinary biomarkers, enhance understanding, but effective treatments remain elusive.

Area of Science:

  • Pediatrics
  • Nephrology

Background:

  • Acute kidney injury (AKI) is a frequent complication in hospitalized children.
  • Recent advancements have improved understanding of pediatric AKI epidemiology, incidence, risk factors, and outcomes.

Purpose of the Study:

  • To summarize current understanding of pediatric acute kidney injury.
  • To highlight advancements in AKI diagnosis and its associated adverse outcomes.

Main Methods:

  • Review of current literature on pediatric AKI.
  • Analysis of diagnostic strategies beyond serum creatinine.
  • Inclusion of oliguria and urinary biomarkers in diagnostic considerations.

Main Results:

  • Pediatric AKI is associated with longer hospital stays and increased mortality.
  • Diagnostic approaches have evolved, emphasizing oliguria and urinary biomarkers.

Conclusions:

  • While diagnostic and definitional progress in pediatric AKI is significant, effective treatments are still needed.
  • Future research should focus on developing and testing interventions for AKI in children.

Keywords:
Acute kidney injuryChildPediatrics

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