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Updated: Feb 17, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Plasmodium P47: a key gene for malaria transmission by mosquito vectors
Alvaro Molina-Cruz1, Gaspar E Canepa1, Carolina Barillas-Mury1
1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, United States.
Abstract:
Malaria is caused by infection with Plasmodium parasites that have a complex life cycle. The parasite protein P47 is critical for disease transmission. P47 mediates mosquito immune evasion in both Plasmodium berghei (Pbs47) and Plasmodium falciparum (Pfs47), and has been shown to be important for optimal female gamete fertility in P. berghei. Pfs47 presents strong geographic structure in natural P. falciparum populations, consistent with natural selection of Pfs47 haplotypes by the mosquito immune system as the parasite adapted to new vector species worldwide. These key functions make Plasmodium P47 an attractive target to disrupt malaria transmission.
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