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Updated: Feb 17, 2026
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Published on: September 22, 2023
Impact of allergy on phenotypic and endotypic profiles of nasal polyposis
G Mortuaire1, I Gengler1, M Balden2
1Service d'ORL et de chirurgie cervico-faciale, hôpital Huriez, CHRU, 59000 Lille, France; Inserm U995, Lille Inflammation Research International Center, université de Lille, 59000 Lille, France.
Objectives:
To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP).
Methods:
A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging. Inflammatory endotypes were determined on biomarker analysis (IgE, IgA, IL-5, IL-9, ECP, EDN) in blood and nasal secretions. Eosinophil counts were obtained in blood, nasal secretions and polyps.
Results:
Phenotype and endotype profiles were comparable in patients with (n=15) or without (n=42) allergy. Only asthma with high total IgE blood concentration showed association with allergy.
Conclusions:
The present results suggest that allergy is not directly involved in the clinical expression and specific inflammatory pathways of CRSwNP. New therapies target inflammation signaling pathways, and identifying accurate blood and tissue biomarkers will be the line of research most likely to improve treatment of CRSwNP.
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