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Programming Morphogenesis through Systems and Synthetic Biology.

Jeremy J Velazquez1, Emily Su2, Patrick Cahan3

  • 1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA; Authors contributed equally.

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|December 13, 2017
PubMed
Summary
This summary is machine-generated.

Scientists are developing new methods to engineer tissue development. By combining synthetic biology, genomics, and modeling, they aim to control complex tissue and organoid morphogenesis from stem cells.

Keywords:
multicellular systemsorganoidssingle cell genomicsstem cell self-organizationsynthetic biologysystems biology

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Synthetic Biology

Background:

  • Mammalian tissue development involves complex self-organization from gene regulatory networks in differentiating stem cells.
  • Understanding these networks and cell interactions is key to engineering morphogenesis.

Purpose of the Study:

  • To review advances in synthetic biology, single-cell genomics, and multiscale modeling.
  • To provide a framework for programming morphogenesis in complex tissues and organoids.

Main Methods:

  • Review of current research in synthetic biology.
  • Analysis of single-cell genomics techniques.
  • Exploration of multiscale modeling approaches.

Main Results:

  • Synthesis of diverse methodologies offers a novel framework.
  • Integration of synthetic biology, genomics, and modeling advances understanding.
  • Potential to program complex tissue and organoid morphogenesis.

Conclusions:

  • The convergence of synthetic biology, single-cell genomics, and multiscale modeling provides a powerful framework.
  • This integrated approach is crucial for achieving robust engineering of mammalian morphogenesis.
  • Future research can leverage this framework to program complex tissue and organoid development.