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Related Concept Videos

Nociception01:44

Nociception

33.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Related Experiment Video

Updated: Feb 17, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Human vs. Mouse Nociceptors - Similarities and Differences.

Charlotte Rostock1, Katrin Schrenk-Siemens1, Jörg Pohle1

  • 1Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.

Neuroscience
|December 13, 2017
PubMed
Summary

Human and mouse pain receptors (nociceptors) show key differences in gene expression. These findings in peptidergic nociceptors may explain challenges in translating rodent pain research to human therapies.

Keywords:
TRP ion channelschronic paindorsal root gangliahuman nociceptorsmarker expressionsensory neurons

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Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Background:

  • The somatosensory system detects stimuli, including pain, crucial for protection.
  • Pathological pain can persist, causing suffering, and rodent models are used to study its mechanisms.
  • Translating rodent pain research findings into human therapies remains a significant challenge.

Purpose of the Study:

  • To compare human and mouse peptidergic (TRKA-expressing) nociceptors.
  • To identify similarities and differences in the expression of key pain-related genes.
  • To provide insights into the difficulties of translating rodent pain models to human conditions.

Main Methods:

  • Dual-color fluorescence in situ hybridization was used on dorsal root ganglia.
  • Transcripts of selected nociceptive markers were compared between humans and mice.
  • Co-expression patterns of specific genes (Trpv1, Nav1.8, Nav1.9, Ret) were analyzed.

Main Results:

  • Significant differences in gene expression were observed between human and mouse nociceptors.
  • Co-expression of Trpv1 with TrkA was higher in humans than in mice.
  • Co-expression of Ret and TrkA, and expression of neurofilament heavy polypeptide, also differed between species.

Conclusions:

  • Comparative analysis reveals species-specific differences in nociceptor gene expression.
  • These molecular differences may underlie the challenges in translating rodent pain research to human therapeutics.
  • Findings suggest a need for revised experimental strategies in pain research.