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Updated: Feb 17, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Kras and Tumor Immunity: Friend or Foe?
Jane Cullis1, Shipra Das1, Dafna Bar-Sagi1
1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016.
Abstract:
With the recent breakthroughs in immunotherapy as curative treatments in certain tumor types, there has been renewed interest in the relationship between immunity and tumor growth. Although we are gaining a greater understanding of the complex interplay of immune modulating components in the tumor microenvironment, the specific role that tumor cells play in shaping the immune milieu is still not well characterized. In this review, we focus on how mutant Kras tumor cells contribute to tumor immunity, with a specific focus on processes induced directly or indirectly by the oncogene.
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