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The Role of Checkpoint Inhibition in Non-Small Cell Lung Cancer

Jonathan Lu1, Robert A Ramirez1,2

  • 1Department of Hematology and Oncology, Ochsner Clinic Foundation, New Orleans, LA.

Ochsner Journal
|December 13, 2017
PubMed
Abstract

Insights

Immune checkpoint inhibitors are revolutionizing cancer treatment, showing promise in advanced non-small cell lung cancer (NSCLC). Research is exploring their use in earlier stages and combination therapies for improved outcomes.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immune checkpoint inhibitors have transformed cancer therapy.
  • Their application in non-small cell lung cancer (NSCLC) is rapidly advancing, particularly for metastatic disease.

Purpose of the Study:

  • To outline the role of immune checkpoint inhibitors in treating malignancy.
  • To review clinical trials of novel immunotherapies for metastatic NSCLC.

Main Methods:

  • Review of clinical trials and existing literature.
  • Analysis of immunotherapy's role in various NSCLC treatment settings.

Main Results:

  • Immunotherapy offers expanded options for patients with metastatic NSCLC, especially after chemotherapy failure.
  • Pembrolizumab is the first immunotherapy approved for first-line NSCLC treatment under specific conditions.

Conclusions:

  • Immune checkpoint inhibitors show significant promise in NSCLC treatment.
  • Ongoing trials investigate adjuvant and combination therapies for enhanced efficacy and broader applications.
Keywords:
Atezolizumabcarcinoma–non-small-cell lungimmunotherapylung neoplasmsnivolumabpembrolizumab

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