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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Long non-coding RNAs in metastasis.

Qihong Huang1, Jinchun Yan2, Reuven Agami3

  • 1Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China. huang19104@yahoo.com.

Cancer Metastasis Reviews
|December 13, 2017
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in cancer metastasis. Understanding lncRNA functions in metastasis can reveal new therapeutic targets and biomarkers.

Keywords:
Long non-coding RNAMetastasislncRNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators of human cellular processes.
  • Aberrant lncRNA expression is prevalent in many cancer types.
  • lncRNAs play significant roles in tumor development and metastasis.

Purpose of the Study:

  • To review the molecular mechanisms of lncRNA gene expression regulation.
  • To elucidate the functions of lncRNAs in cancer metastasis.
  • To identify potential therapeutic targets and biomarkers for metastasis.

Main Methods:

  • Literature review of recent studies on lncRNAs and metastasis.
  • Analysis of molecular mechanisms underlying lncRNA function in gene expression.
  • Synthesis of current knowledge on lncRNA roles in tumor metastasis.

Main Results:

  • lncRNAs regulate gene expression at multiple levels.
  • Specific lncRNAs are involved in key steps of tumor metastasis.
  • Dysregulated lncRNAs contribute to cancer progression and spread.

Conclusions:

  • lncRNAs are crucial players in cancer metastasis.
  • Further research into lncRNA mechanisms can improve understanding of metastasis.
  • lncRNAs represent promising targets for anti-metastasis therapies and diagnostic biomarkers.