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Chemotherapy-induced eccrine squamous syringometaplasia in an infant

Peter G Bittar1, Megan Casady2, Maria A Selim2,3

  • 1School of Medicine, Duke University, Durham, NC, USA.

Pediatric Dermatology
|December 13, 2017
PubMed

Insights

This study details the first reported case of chemotherapy-induced eccrine squamous syringometaplasia in an infant. The condition developed after bone marrow transplant conditioning with busulfan, fludarabine, and antithymocyte globulin.

Area of Science:

  • Pediatric Oncology
  • Dermatology
  • Hematology

Background:

  • Chemotherapy-induced eccrine squamous syringometaplasia (CIES) is a rare cutaneous reaction.
  • Reports in pediatric populations are scarce, necessitating further clinical documentation.

Observation:

  • An infant undergoing bone marrow transplantation developed skin lesions post-conditioning therapy.
  • Lesions presented as erythematous papules and plaques in intertriginous areas and adhesive sites.
  • Histopathological examination revealed characteristic eccrine gland changes.

Findings:

  • The infant exhibited symptoms consistent with CIES following treatment with busulfan, fludarabine, and antithymocyte globulin.
  • Biopsy confirmed dyskeratotic cells and squamous metaplasia within eccrine glands.
  • This represents the first documented pediatric case of CIES in an infant.

Implications:

  • This case expands the understanding of CIES presentation in pediatric patients.
  • Highlights the importance of recognizing CIES as a potential adverse effect of specific chemotherapy regimens.
  • Informs clinical vigilance for dermatological side effects in pediatric bone marrow transplant recipients.

Keywords:
chemotherapyeccrine squamous syringometaplasiainfant

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