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Circadian rhythm in atopic dermatitis-Pathophysiology and implications for chronotherapy
Alexandra R Vaughn1,2, Ashley K Clark1, Raja K Sivamani1,3
1Department of Dermatology, University of California, Davis, Sacramento, CA, USA.
Pediatric Dermatology
|December 13, 2017
Summary
Circadian rhythms regulate skin functions and barrier properties. Disruptions to these biological clocks may contribute to atopic dermatitis (AD), suggesting chronotherapy could improve AD treatment.
Area of Science:
- Dermatology and chronobiology.
- Investigating the interplay between biological rhythms and skin health.
Background:
- Circadian rhythms, controlled by an endogenous brain clock, govern daily physiological cycles.
- Cutaneous diurnal rhythms influence skin functions like blood flow and barrier properties (e.g., transepidermal water loss).
- These rhythms are modulated by external factors such as temperature, humidity, diet, and stress.
Purpose of the Study:
- To explore the role of circadian rhythm aberrations in the pathogenesis of atopic dermatitis (AD).
- To propose chronotherapy as a potential treatment strategy for improving outcomes in AD patients.
Main Methods:
- This is a review article.
- It synthesizes current research on circadian rhythms and skin physiology.
- It specifically examines the link between circadian dysfunction and atopic dermatitis.
Main Results:
- Circadian rhythm influences key skin functions, including blood flow and barrier integrity.
- Aberrations in circadian rhythm are implicated in the development and progression of atopic dermatitis.
- Chronotherapy, aligning treatments with the body's natural rhythms, shows promise for managing AD.
Conclusions:
- Disrupted circadian rhythms are a potential contributing factor to atopic dermatitis pathogenesis.
- Implementing chronotherapy may offer a novel and effective approach to managing atopic dermatitis.
- Further research into circadian mechanisms in AD is warranted to optimize therapeutic strategies.
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