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Updated: Feb 17, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hypertrophic Cardiomyopathy-Past, Present and Future

Alphonsus C Liew1, Vassilios S Vassiliou2,3,4, Robert Cooper5

  • 1Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK. Alphonsus.liew@hotmail.com.

Journal of Clinical Medicine
|December 13, 2017
PubMed

Insights

Hypertrophic cardiomyopathy (HCM), a common genetic heart condition, has seen significant advancements in understanding, diagnosis, and management since its initial description. This review covers its history, current guidelines, and future developments.

Area of Science:

  • Cardiology
  • Genetics
  • Medical History

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiomyopathy, affecting approximately 1 in 500 individuals.
  • The understanding of HCM has evolved significantly since the first pathological case series in 1957.
  • This condition presents complex diagnostic and management challenges.

Purpose of the Study:

  • To provide a historical overview of the understanding of hypertrophic cardiomyopathy.
  • To review current diagnostic methods and treatment options for HCM.
  • To identify evidence gaps and discuss emerging developments in HCM research and care.

Main Methods:

  • Literature review of historical pathological findings.
  • Analysis of current diagnostic guidelines and treatment strategies.
  • Discussion of recent research and future directions in HCM.

Main Results:

  • Detailed historical progression of HCM knowledge from initial findings to current understanding.
  • Comprehensive overview of established diagnostic tools and therapeutic interventions.
  • Identification of areas requiring further research and promising novel approaches.

Conclusions:

  • HCM understanding has advanced considerably, improving patient outcomes.
  • Current guidelines provide a framework for diagnosis and management.
  • Future research holds promise for more targeted and effective HCM therapies.

Keywords:
HCMLVOThypertrophic cardiomyopathyleft ventricular outflow tract obstruction

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