[Clinical pictures of borreliosis]

Lyme disease occurs in a variety of clinical manifestations, ranging from skin lesions, through musculoskeletal, neurological, and cardiac syndrome, to severe irreversible lesions. Borrelia burgdorferi's organotropy has an impact on the development of the disease. In initial management, it is important to implement effective treatment to prevent further progression of infection. Dominant skin lesions should be differentiated in detail. In the form of disseminated disease complex of clinical syndromes is observed but it requires of confirmation in immunoassays. A particular difficulty in the management of the posttreatment Lyme borreliosis syndrome is when a severe disease of the organ is present. Symptoms appear after months or years after antibiotic therapy in 10-20% of patients. In patients with a syndrome, a clinical picture may develop as an autoimmune response that has developed after active infection and effective treatment that could have eradicated the causative agent. It has also been shown that the presence of persistent inactive microorganisms after antibiotic treatment can trigger local symptoms. The complexity of the clinical picture of Lyme disease requires a reliable diagnosis and a wide variety of pathologies.