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The Diuretic Potential of Sacubitril/Valsartan: A Tale of 2 Patients

Sabrina M Hormann1, Lindsay E Davis, Elizabeth K Pogge

  • 1Sabrina M. Hormann, PharmD Compounding Pharmacist, Potter's House Apothecary, Peoria, Arizona. Lindsay E. Davis, PharmD, BCPS, ASH-CHC, TTS Associate Professor, College of Pharmacy-Glendale, Midwestern University, Arizona. Elizabeth K. Pogge, PharmD, MPH, BCPS-AQ (Cardiology), FASCP Associate Professor, College of Pharmacy-Glendale, Midwestern University, Arizona.

The Journal of Cardiovascular Nursing
|December 13, 2017
PubMed

Insights

Angiotensin receptor-neprilysin inhibitor (ARNi) therapy in heart failure patients led to improved fluid balance and reduced diuretic needs. This suggests ARNi promotes beneficial diuresis, potentially optimizing treatment regimens.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Rising heart failure prevalence in the US incurs significant morbidity, mortality, and healthcare costs.
  • 2016 guidelines recommend angiotensin receptor-neprilysin inhibitors (ARNi) for stage C heart failure with reduced ejection fraction (HFrEF).
  • ARNi therapy is advised for chronic HFrEF patients (NYHA class II-III) to further reduce morbidity and mortality.
Abstract

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