The association of keratoconus with blepharitis

Area of Science:

• Ophthalmology
• Corneal Diseases
• Ocular Surface Disease

Background:

• Identifying treatable risk factors for keratoconus progression is crucial.
• Keratoconus is a progressive corneal ectasia.
• The association between blepharitis and keratoconus requires further investigation.

Purpose of the Study:

• To determine the association between blepharitis and keratoconus.
• To investigate if blepharitis is a risk factor for keratoconus.

Main Methods:

• Prospective, comparative, observational study.
• 50 keratoconus participants and 72 healthy controls.
• Comprehensive eye examinations, eyelid surveys, and validated questionnaires (Ocular Surface Disease Index).

Main Results:

• Blepharitis prevalence was significantly higher in keratoconus patients (24%) compared to controls (2.8%).
• Keratoconus participants reported more frequent eye rubbing (36% vs 11.1%) and symptoms of red, tired eyes.
• Signs of blepharitis and meibomian gland dysfunction were more frequent in the keratoconus group.

Conclusions:

• Blepharitis signs and symptoms are more prevalent in keratoconus patients.
• Blepharitis-related inflammation and eye rubbing may contribute to keratoconus progression.
• Targeting blepharitis could be a potential therapeutic strategy for managing keratoconus.