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The Keap1-Nrf2 protein-protein interaction: A suitable target for small molecules

Dieter Schmoll1, Christian K Engel1, Heiner Glombik1

  • 1Sanofi R&D, Industriepark Hoechst, D-65926 Frankfurt, Germany.

Drug Discovery Today. Technologies
|December 14, 2017
PubMed
Summary

Nuclear factor erythroid 2-related factor 2 (Nrf2) is key in oxidative stress defense. New reversible inhibitors of the Keap1-Nrf2 interaction may prove Nrf2 activation

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