Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transtracheal oxygen decreases inspired minute ventilation.

J I Couser1, B J Make

  • 1Pulmonary Center, Boston University School of Medicine, Massachusetts 02118.

The American Review of Respiratory Disease
|March 1, 1989
PubMed
Summary

Transtracheal oxygen (TTO2) therapy reduces minute ventilation (VI) by decreasing tidal volume, not respiratory rate. This reduction in VI may explain improved exercise tolerance and reduced dyspnea in patients receiving TTO2.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.

The pharmacogenomics journal·2015
Same author

Candidate genes for COPD in two large data sets.

The European respiratory journal·2010
Same author

Quality of life measured with a generic instrument (Short Form-36) improves following pulmonary rehabilitation in patients with COPD.

Chest·2001
Same author

Effective implementation of practice guidelines.

Chest·1998
Same author

Mechanical ventilation beyond the intensive care unit. Report of a consensus conference of the American College of Chest Physicians.

Chest·1998
Same author

Improved exercise performance following lung volume reduction surgery for emphysema.

American journal of respiratory and critical care medicine·1998

Area of Science:

  • Respiratory Physiology
  • Pulmonary Medicine

Background:

  • Patients using transtracheal oxygen (TTO2) report reduced dyspnea and improved exercise tolerance.
  • The underlying physiological mechanisms for these benefits remain unclear.

Purpose of the Study:

  • To investigate the effect of TTO2 on inspired minute ventilation (VI) in patients with chronic hypoxemia.
  • To determine if reduced VI contributes to the observed clinical improvements.

Main Methods:

  • Seven patients with chronic hypoxemia (COPD or restrictive lung disease) were studied.
  • Inspired minute ventilation (VI), exhaled minute ventilation (VE), respiratory rate (RR), tidal volume (VT), and blood gases were measured during TTO2 and mouth oxygen delivery.
  • Five patients also received air transtracheally to assess the effect independent of oxygenation.

Related Experiment Videos

Main Results:

  • TTO2 significantly reduced VI compared to mouth oxygen delivery at equivalent oxygenation levels.
  • VI decreased as TTO2 flow rate increased, primarily due to a reduction in tidal volume (VT).
  • Transtracheal air delivery also reduced VI compared to breathing air via the mouth.

Conclusions:

  • Delivering oxygen or air transtracheally decreases inspired minute ventilation (VI).
  • The reduction in VI is flow-dependent and not solely attributable to improved oxygenation.
  • Decreased VI and potentially reduced inspiratory work of breathing may underlie the benefits of TTO2 therapy.