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Autophagy in health and disease: focus on the cardiovascular system

Jeanne Mialet-Perez1, Cécile Vindis2

  • 1INSERM UMR1048, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, Toulouse, France.

Essays in Biochemistry
|December 14, 2017
PubMed

Insights

Autophagy, a cellular degradation process, is vital for cardiovascular health. Dysfunctional autophagy contributes to heart failure and atherosclerosis, highlighting its complex role in cardiovascular disorders.

Area of Science:

  • Cellular Biology
  • Physiology
  • Pathophysiology

Background:

  • Autophagy is a fundamental cellular process for degrading damaged proteins and organelles.
  • It is crucial for maintaining cellular homeostasis across various tissues.
  • Recent research highlights specific roles for autophagy in diverse organs.

Purpose of the Study:

  • To review the current understanding of autophagy within the cardiovascular system.
  • To explore the physiological functions of cardiovascular autophagy.
  • To examine the pathophysiological implications of autophagy in cardiovascular diseases.

Main Methods:

  • Literature review of existing research on cardiovascular autophagy.
  • Synthesis of data on autophagy's role in heart and vessel homeostasis.
  • Analysis of studies linking autophagy to cardiovascular disorders.

Main Results:

  • Autophagy is essential for maintaining normal heart and vessel function.
  • Both insufficient and excessive autophagy are implicated in cardiovascular pathology.
  • Specific roles are identified in conditions like heart failure and atherosclerosis.

Conclusions:

  • Cardiovascular autophagy plays a dual role, being critical for health but detrimental when dysregulated.
  • Understanding autophagy modulation is key for treating cardiovascular diseases.
  • Further research is warranted to elucidate precise mechanisms and therapeutic targets.

Keywords:
autophagycardiovascular diseasecardiovascular physiology

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