Related Experiment Video
Updated: Feb 17, 2026
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
11.1K
Matrix Metalloproteinases (MMPs) in Liver Diseases
Adnan Naim1, Qiuwei Pan2, Mirza S Baig1
1Centre for Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Indore, India.
Journal of Clinical and Experimental Hepatology
|December 14, 2017
Summary
Matrix metalloproteinases (MMPs) are enzymes that break down extracellular matrix. MMPs are involved in liver disease pathogenesis, influencing cell activities and inflammation, suggesting they are key players in liver disease outcomes.
Area of Science:
- Biochemistry
- Molecular Biology
- Hepatology
Background:
- Matrix metalloproteinases (MMPs) are enzymes that degrade extracellular matrix components and other proteins.
- MMPs and their inhibitors are implicated in the development of liver diseases.
- The exact roles of MMPs in liver disorders are not fully understood.
Purpose of the Study:
- To explore the role of MMPs in the pathogenesis of liver diseases.
- To understand how MMPs influence cellular activities and inflammation in the liver.
Main Methods:
- Review of experimental models and existing data on MMPs in liver disease.
- Analysis of MMPs' effects on cellular proliferation, survival, gene expression, and inflammation.
Main Results:
- MMPs influence key cellular processes relevant to liver disease, including proliferation, survival, and gene expression.
- MMPs play a significant role in modulating inflammatory responses within the liver.
- Data suggests MMPs are critical in determining the progression and outcomes of liver diseases.
Conclusions:
- Matrix metalloproteinases (MMPs) are significantly involved in the pathogenesis of liver diseases.
- MMPs impact cellular functions and inflammation, highlighting their importance in liver health and disease.
- Further research into MMPs' mechanisms is crucial for understanding and potentially treating liver disorders.
Keywords:
Col, collagenECM, extra cellular matrixGBD, global burden of diseaseHCC, hepato-cellular carcinomaIRI, ischemia and reperfusion injuryMMP, matrix metalloproteasesNAFLD, non-alcoholic fatty liver diseaseNFkB, nuclear factor kappa-BTIMPs, tissue inhibitors of MMPsTNF, tumor necrosis factorcirrhosisextracellular matrix (ECM)hepatocellular carcinomaliver fibrosismatrix metalloproteinases
Related Concept Videos
01:23Role of Matrix Metalloproteases in Degradation of ECM
3.5K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.5K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
212
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
212
01:24Liver Regeneration
4.5K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.5K