Genetic alterations in benign prostatic hyperplasia patients.
Hanaa Mahmoud Mohamed1, Magdy Sayed Aly1, Tarek Dardeer Hussein2
1Cell Biology and Genetics Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
German Medical Science : GMS E-Journal
|December 14, 2017
Summary
Benign prostate hyperplasia (BPH) genetic markers HER-2/neu, c-myc, and p53 were investigated. p53 gene deletion was linked to severe urinary symptoms, suggesting potential diagnostic and therapeutic roles in BPH management.
Area of Science:
- Urology
- Oncology
- Genetics
Background:
- Benign prostate hyperplasia (BPH) is a common age-related condition affecting a significant percentage of men over 40.
- BPH causes lower urinary tract symptoms that impact daily life.
- Understanding the molecular underpinnings of BPH is crucial for improved patient outcomes.
Purpose of the Study:
- To investigate the association between specific genetic markers (HER-2/neu, c-myc, p53) and clinicopathological variables in BPH patients.
- To explore the potential of these genetic markers as diagnostic or prognostic indicators.
- To identify potential therapeutic targets for BPH.
Main Methods:
- Analysis of 45 BPH patients undergoing transurethral prostate resection.
- Utilized fluorescence in situ hybridization (FISH) to assess gene amplification/deletion.
- Evaluated clinicopathological variables, including age, PSA levels, prostate volume, and symptom scores (AUASI).
Main Results:
- HER-2/neu amplification in 8.9% and c-myc amplification in 11.1% of cases, with no association to adverse clinicopathological variables.
- p53 gene deletion observed in 44.4% of patients.
- p53 deletion showed a significant association with severe American Urological Association Symptom Index (AUASI) scores.
Conclusions:
- Genetic markers HER-2/neu, c-myc, and p53 play a role in BPH.
- p53 gene deletion is linked to more severe urinary symptoms in BPH patients.
- These genetic markers may serve as future diagnostic, prognostic, and therapeutic targets for BPH.
Keywords:
BPHFISHamplificationbenign prostatic hyperplasiadeletionfluorescence in situ hybridizationgenesMore Related Videos
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