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Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus

Bei Jiang1, Yinan Wang2, Zihan Feng3

  • 1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, China.

Frontiers in Microbiology
|December 14, 2017
PubMed

Insights

Staphylococcus aureus osteomyelitis (OM) is challenging. Panton-Valentine leukocidin (PVL) genes indicate higher prevalence, longer duration, and increased severity in S. aureus OM, aiding prognosis and treatment.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Orthopedics

Background:

  • Staphylococcus aureus is a leading cause of osteomyelitis (OM).
  • Effective diagnosis and management of S. aureus OM, particularly severe or chronic cases, require predictive indicators.
  • Identifying molecular and clinical factors associated with OM prevalence, duration, and severity is crucial.

Purpose of the Study:

  • To identify indicators associated with Staphylococcus aureus osteomyelitis (OM) prevalence.
  • To determine factors influencing OM duration and severity.
  • To evaluate the role of specific virulence genes in S. aureus OM.

Main Methods:

  • Compared molecular types, antimicrobial susceptibility, and virulence factors of S. aureus isolates from OM and non-OM patients.
  • Analyzed clinical manifestations and laboratory data to assess OM duration and severity.
  • Investigated the association of specific genes (pvl, bbp, ebps, sei) with OM characteristics.

Main Results:

  • Specific sequence types of S. aureus were linked to OM infection.
  • The pvl, bbp, and ebps genes correlated with S. aureus OM prevalence.
  • The pvl, bbp, and sei genes were associated with longer OM duration.
  • Panton-Valentine leukocidin (PVL)-positive S. aureus OM exhibited more severe inflammatory responses.

Conclusions:

  • Panton-Valentine leukocidin (PVL) significantly impacts the prevalence, duration, and severity of S. aureus osteomyelitis.
  • PVL-positive S. aureus OM requires careful monitoring for better prognosis and treatment.
  • Identifying PVL-related S. aureus OM can guide clinical management and improve patient outcomes.
Keywords:
Panton-Valentine leucocidin (PVL)Staphylococcus aureusmolecular epidemiologyosteomyelitisvirulence factor

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