Related Experiment Video
Updated: Feb 17, 2026
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
1.4K
The Future of Immunotherapy: A 20-Year Perspective
1Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Frontiers in Immunology
|December 14, 2017
Summary
Immunotherapy, which modulates immune responses, is advancing rapidly. Activating immunotherapies target cancer, while suppressive ones address autoimmune diseases, offering new hope for treatment.
Area of Science:
- Immunology
- Translational Medicine
Background:
- Immunotherapy involves manipulating immune responses for disease treatment.
- Two main types exist: activating (for cancer) and suppressive (for autoimmunity).
- Both fields are experiencing renewed interest and potential for significant clinical impact.
Purpose of the Study:
- To provide a perspective on activating immunotherapies for cancer.
- To discuss suppressive immunotherapies for autoimmune diseases.
- To highlight the distinct approaches and differing side-effect tolerances for these two immunotherapy types.
Main Methods:
- This perspective reviews current research and future directions in cancer immunotherapy.
- It also examines advancements in immunotherapy for autoimmune conditions.
- The focus is on contrasting the strategies and clinical considerations for each.
Main Results:
- Activating immunotherapies for cancer aim to boost anti-tumor immunity.
- Suppressive immunotherapies for autoimmunity seek to dampen self-reactive immune responses.
- Acceptable side-effect profiles differ significantly between cancer and autoimmune disease treatments.
Conclusions:
- Immunotherapy holds promise for transforming treatments in oncology and rheumatology.
- Distinct therapeutic strategies are required for activating versus suppressive immunotherapy.
- Future research will likely refine these approaches, improving patient outcomes.
Related Concept Videos
01:27Tumor Immunotherapy
2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
01:30Cancer Vaccines
1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
01:29Microorganisms in Medicine and Therapeutics
1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
02:50Combination Therapies and Personalized Medicine
6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
01:31Hybridoma Technology
17.8K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.8K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K