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Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats
Juan Li1, Yu-Mei Zhang1, Jun-Yi Li1
1Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
Background And Aims:
Obesity has become the main public health issue nowadays with poor control and has been associated with increased risk of multiorgan disease, but the specific mechanism and effective medication are still to be addressed. Sheng-jiang powder (SJP) showed great potential in preventing obesity in Chinese researches but has no trace in English reports. This study was designed to investigate the effect of SJP on obesity and obesity-mediated multiorgan injuries.
Methods:
Rats were randomized into normal group (NG), obese group (OG), and SJP treatment group (SG). Obesity was induced by high-fat diet feeding. Rats were gavaged with SJP/normal saline daily from the third week and all rats were sacrificed after 12 weeks' feeding. Tissues were obtained for cytokines tests.
Results:
Firstly, high-fat diet feeding led to significant obesity. Compared to NG, the level of SOD in the liver, spleen, lung, and kidney was much lower in OG (p < 0.05), while the pathological scores of pancreas, liver, spleen, lung, and kidney were much higher. SJP significantly increased SOD level in the liver, spleen, and lung and reduced the pathological scores of pancreas, liver, spleen, lung, and kidney correspondingly (p < 0.05).
Conclusions:
SJP ameliorates inflammatory response and mitigates obesity-induced multiple organ injuries.
Insights
Sheng-jiang powder (SJP) effectively combats obesity and reduces organ damage in rats. This study shows SJP improves antioxidant levels and lowers inflammation, mitigating health issues linked to obesity.
Area of Science:
- Pharmacology
- Toxicology
- Integrative Medicine
Background:
- Obesity is a major global health concern linked to multiorgan disease.
- Effective treatments for obesity and its complications are urgently needed.
- Sheng-jiang powder (SJP) shows promise in traditional Chinese medicine for obesity prevention.
Purpose of the Study:
- To investigate the therapeutic effects of Sheng-jiang powder (SJP) on diet-induced obesity.
- To evaluate SJP's impact on obesity-related multiorgan injuries in a rat model.
Main Methods:
- Obesity was induced in rats using a high-fat diet over 12 weeks.
- Rats were treated daily with SJP or saline.
- Liver, spleen, lung, and kidney tissues were analyzed for antioxidant levels (SOD) and pathological changes.
Main Results:
- High-fat diet induced significant obesity and increased pathological scores in multiple organs.
- Obese rats showed significantly lower SOD levels in the liver, spleen, lung, and kidney.
- SJP treatment significantly increased SOD levels and reduced pathological damage in these organs.
Conclusions:
- Sheng-jiang powder (SJP) demonstrates efficacy in ameliorating obesity-induced inflammation.
- SJP mitigates multiorgan injuries associated with obesity in a preclinical model.
- SJP represents a potential therapeutic agent for managing obesity and its complications.
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