Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

4.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple Dorsal Hand Actinic Keratoses and Squamous Cell Carcinomas: A Unique Presentation following Extensive UV Nail Lamp Use.

Case reports in dermatology·2019
Same author

Atypical Mycobacterial Infection Arising Amid Corticosteroid Therapy for Livedoid Vasculopathy.

Case reports in dermatological medicine·2019
Same author

Epitope spread in chronic mucosal GVHD: mucous membrane pemphigoid resolution with rituximab.

International journal of dermatology·2018
Same author

Perniosis (chilblains) masquerading as CA-MRSA: a case report.

Cases journal·2009

Related Experiment Video

Updated: Feb 17, 2026

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

12.0K

Repigmentation of Tenacious Vitiligo on Apremilast.

Sara B Huff1, Lorie D Gottwald2

  • 1University of Toledo College of Medicine and Life Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USA.

Case Reports in Dermatological Medicine
|December 14, 2017
PubMed
Summary

Vitiligo, a depigmentation disorder, presents treatment challenges. Apremilast, a psoriasis drug, showed repigmentation success in a severe, long-standing vitiligo case.

More Related Videos

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.5K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.3K

Related Experiment Videos

Last Updated: Feb 17, 2026

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

12.0K
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.5K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.3K

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Vitiligo is a common autoimmune pigment disorder causing melanocyte loss and depigmentation.
  • Current vitiligo treatments are limited due to poorly understood disease mechanisms.
  • Patients often have co-occurring autoimmune conditions.

Observation:

  • A 52-year-old woman with a 20-year history of vitiligo presented with recalcitrant disease.
  • She had previously shown no response to multiple treatment modalities.

Findings:

  • Apremilast, an FDA-approved medication for psoriasis and psoriatic arthritis, was administered.
  • The patient experienced significant repigmentation.

Implications:

  • This case suggests apremilast may be a viable treatment option for severe, treatment-resistant vitiligo.
  • Further research into apremilast for vitiligo is warranted.
  • Understanding apremilast's mechanism in vitiligo could offer new therapeutic insights.