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Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies
Published on: June 30, 2023
Therapeutic approaches for corneal neovascularization
Sepehr Feizi1, Amir A Azari1, Sharareh Safapour1
1Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, 16666 Iran.
Abstract:
Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid administration, laser treatment, cautery, and fine needle diathermy. Since the imbalance between proangiogenic agents and antiangiogenic agents primarily mediate the process of corneal neovascularization, recent therapies are intended to disrupt the different steps in the synthesis and actions of proangiogenic factors. These approaches, however, are only partially effective and may lead to several side effects. The aim of this article is to review the most relevant treatments for corneal neovascularization available so far.
Insights
Corneal neovascularization, the growth of new blood vessels in the cornea, can impair vision. This review examines current treatments for this condition, highlighting their varying success and side effects.
Area of Science:
- Ophthalmology
- Vascular Biology
Background:
- Corneal neovascularization involves new blood vessel growth from existing vessels in the cornea.
- This condition can significantly reduce visual acuity and is associated with various corneal diseases.
- Current treatments have shown limited success and potential side effects.
Purpose of the Study:
- To review existing therapeutic strategies for corneal neovascularization.
- To discuss the mechanisms underlying corneal neovascularization.
- To evaluate the efficacy and limitations of current treatments.
Main Methods:
- Literature review of established and emerging treatments for corneal neovascularization.
- Analysis of therapeutic approaches including corticosteroids, laser therapy, cautery, and diathermy.
- Examination of therapies targeting proangiogenic and antiangiogenic factors.
Main Results:
- Various treatments exist, including topical corticosteroids, laser, cautery, and diathermy.
- Therapies targeting angiogenic factors aim to disrupt their synthesis and action.
- Existing treatments offer partial effectiveness and can cause side effects.
Conclusions:
- Corneal neovascularization is a complex condition requiring effective treatment strategies.
- Current therapies provide varying degrees of success and are associated with side effects.
- Further research into novel treatments is essential for managing corneal neovascularization.
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