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Point of care testing of fecal calprotectin as a substitute for routine laboratory analysis
Julie Hejl1, Klaus Theede2, Brian Møllgren1
1Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650 Hvidovre, Denmark.
Objectives:
Fecal calprotectin (FC) is widely used to monitor the activity of inflammatory bowel disease (IBD) and to tailor medical treatment to disease activity. Laboratory testing of fecal samples may have a turnaround time of 1-2 weeks, whereas FC home testing allows results within hours and thus enables a rapid response to clinical deterioration.
Design And Methods:
Fifty-five stool samples were analyzed by the IBDoc® Calprotectin Home Testing kit and the BÜHLMANN fCAL® turbo assay on a Roche Cobas 6000 c501. The correlation between the assays was assessed using Spearman's Rho correlation coefficient and the intermediate imprecision of both assays was calculated.
Results:
We found a strong correlation coefficient of 0.887 between FC measured on IBDoc® and the laboratory assay BÜHLMANN fCAL® turbo. The coefficients of variation (CVs) at three different FC levels were in the range 2.3-5.5% (BÜHLMANN fCAL® turbo) and in the range of 4.8-26.6% (IBDoc®).
Conclusions:
This study suggests that IBDoc® is a suitable alternative for the assessment of disease activity in IBD patients.
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