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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
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[Mesenchymal abdominal tumors in children]
1Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Giessen, Justus-Liebig Universität Giessen, Klinikstraße 33, 35392, Giessen, Deutschland. gabriele.krombach@uniklinikum-giessen.de.
Der Radiologe
|December 14, 2017
Summary
Pediatric mesenchymal tumors vary in presentation. Imaging, particularly sonography and MRI, is crucial for diagnosis and staging, while avoiding biopsy if nephroblastoma is suspected to prevent metastasis.
Area of Science:
- Pediatric oncology
- Radiology
- Surgical pathology
Background:
- Mesenchymal tumors in children present diverse clinical features.
- Diagnosis can be challenging, necessitating advanced imaging techniques.
- Biopsy carries risks, especially for specific diagnoses like nephroblastoma.
Purpose of the Study:
- To outline the diagnostic approach for pediatric mesenchymal tumors.
- To emphasize the role of imaging in differential diagnosis and staging.
- To highlight precautions regarding biopsy in suspected nephroblastoma.
Main Methods:
- Review of imaging modalities including sonography, MRI, and low-dose CT.
- Discussion of clinical presentation and age-specific manifestations.
- Emphasis on avoiding biopsy in cases with suspected nephroblastoma.
Main Results:
- Sonography and MRI are key for pediatric tumor evaluation.
- Imaging helps define lesion extent and facilitates staging.
- Low-dose CT is vital for detecting pulmonary metastases.
Conclusions:
- Imaging is paramount for diagnosing and staging pediatric mesenchymal tumors.
- Careful consideration of biopsy is essential, particularly to avoid tract metastasis in nephroblastoma.
- A multidisciplinary approach integrating imaging and clinical data improves patient outcomes.
