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Updated: Feb 17, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
[Neuroendocrine tumors of the abdomen]
1Diagnostische und Interventionelle Radiologie, Klinikum Konstanz, Luisenstraße 7, 78464, Konstanz, Deutschland. markus.juchems@klinikum-konstanz.de.
Clinical/Methodical Issue:
Gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) are a heterogeneous group of complex tumors, which is often difficult to classify due to heterogeneity and varying locations.
Standard Radiological Methods:
Ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron-emission tomography computed tomography (PET/CT) are available for the localization of NEN as well as for the staging.
Methodological Innovations:
In particular, nuclear medical examination methods with somatostatin analogues are of great importance since radioactively labeled receptor ligands make tumors visible with high sensitivity.
Performance:
CT and MRT have high detection rates for GEP-NEN and have been further improved by developments such as diffusion weighted imaging. The nuclear medical methods, however, are superior in detection, especially in gastrointestinal NEN ACHIEVEMENTS: It is important for the radiologist to become acquainted with the NEN as they can occur ubiquitously in the abdomen and should be identified as such.
Practical Recommendations:
Since GEP-NEN are predominantly hypervascularized, a biphasic examination technique is obligatory for contrast-enhanced cross-sectional imaging. PET/CT with somatostatin analogs should be used for further diagnosis.
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