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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Atrial thrombogenesis in atrial fibrillation : Results from atrial fibrillation models and AF-patients

Alicja Bukowska1, Matthias Hammwöhner2, Domenico Corradi3

  • 1Working Group of Molecular Electrophysiology, Institute of Clinical Chemistry and Pathobiochemistry, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Herzschrittmachertherapie & Elektrophysiologie
|December 14, 2017
PubMed

Insights

Atrial fibrillation (AF) increases stroke risk. This review details AF thrombogenesis and prothrombotic endocardial remodeling, supporting anticoagulation and potential therapies like statins to prevent clots.

Area of Science:

  • Cardiology
  • Thrombosis Research
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is the leading cause of thromboembolic events.
  • Risk stratification for thromboembolism in AF patients uses the CHA2DS2-VASc score.
  • Left atrial appendage is the primary site for thrombus formation in AF.

Purpose of the Study:

  • To review the pathophysiology of thrombogenesis in AF.
  • To elucidate the molecular mechanisms of prothrombotic endocardial remodeling.
  • To identify potential adjunctive therapies to oral anticoagulation.

Main Methods:

  • Literature review of existing studies on AF pathophysiology.
  • Analysis of molecular pathways involved in atrial thrombosis.
  • Synthesis of data on risk factors and therapeutic interventions.

Main Results:

  • Thrombi in AF originate from the left atrial appendage.
  • Prothrombotic endocardial remodeling is a key molecular process.
  • Oral anticoagulation is the primary treatment, but other therapies may be beneficial.

Conclusions:

  • Understanding AF thrombogenesis is crucial for preventing thromboembolic complications.
  • Targeting prothrombotic endocardial remodeling could offer new therapeutic strategies.
  • Concomitant therapies, such as statins and angiotensin II blockers, may enhance clot prevention in AF.

Keywords:
Angiotensin IIAnticoagulationEndocardiumStrokeTherapy

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