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The Tail Suspension Test
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Trace lithium and mental health.

Nobuyoshi Ishii1, Takeshi Terao2

  • 1Department of Neuropsychiatry, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Yufu, Oita, 879-5593, Japan. nobuy@oita-u.ac.jp.

Journal of Neural Transmission (Vienna, Austria : 1996)
|December 14, 2017
PubMed
Summary

Trace lithium shows potential for suicide prevention, but more research is needed. Evidence for its use in bipolar disorder, dementia, and temperament is currently limited and requires further investigation.

Keywords:
Bipolar disorderDementiaLithiumSuicideTemperamentTrace lithium

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a standard treatment for bipolar disorder and augmentation for depression.
  • Lithium's role in suicide, dementia, and aggression has been explored.
  • Trace amounts of lithium are increasingly being studied for mental health applications.

Purpose of the Study:

  • To review existing literature on the effects of trace lithium on mental state.
  • To assess the efficacy of trace lithium in treating suicide, dementia, bipolar disorder, and temperament.
  • To determine the current evidence supporting trace lithium's use in psychiatric conditions.

Main Methods:

  • Literature review of articles concerning trace lithium.
  • Analysis of studies investigating lithium's impact on suicide, dementia, bipolar disorder, and temperament.
  • Assessment of the quality and limitations of existing evidence.

Main Results:

  • Trace lithium may offer benefits for suicide prevention.
  • Robust evidence from randomized, placebo-controlled trials is necessary to confirm suicide prevention efficacy.
  • Limited evidence currently supports the use of trace lithium for dementia, bipolar disorder, and temperament.

Conclusions:

  • Trace lithium shows promise for suicide prevention, warranting further rigorous clinical trials.
  • The therapeutic effects of trace lithium on dementia, bipolar disorder, and temperament remain largely undetermined.
  • More research is essential to establish definitive conclusions regarding trace lithium's role in mental health treatment.