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Updated: Feb 17, 2026

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
Published on: October 24, 2019
Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy
Huang Zhu1, Yi-Shin Lai1, Ye Li1
1Department of Medicine, Division of Regenerative Medicine, University of California San Diego, San Diego, California, USA.
Abstract:
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers. Stem Cells 2018;36:134-145.
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