Retracted: Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis
Abstract:
Following on from the Expression of Concern (10.1002/glia.22466) previously published by GLIA, the following Original Article has been retracted by the journal Editors and Publisher: Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis By Milena Penkowa and Juan Hidalgo GLIA (2000), 32(3), 247-263 DOI: 10.1002/1098-1136(200012)32:3<247::AID-GLIA50>3.0.CO;2-T Discrepancies in the type and number of animals used in experiments performed by Milena Penkowa and reported in Table 1, identified during the course of investigations into Ms Penkowa's research, render the data and conclusions drawn from them unreliable.
Insights
This study on metallothionein I+II expression in experimental autoimmune encephalomyelitis is retracted due to unreliable data. Discrepancies in animal models and numbers used make the findings questionable.
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Metallothioneins (MTs) are proteins involved in cellular defense.
- Their role in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, was investigated.
Purpose of the Study:
- To examine the expression of metallothionein I+II.
- To determine the role of these proteins in the pathogenesis of EAE.
Main Methods:
- The study involved experiments with animals to model EAE.
- Analysis of metallothionein I+II expression was performed.
Main Results:
- The original article reported specific findings on metallothionein expression in EAE.
- However, these results are now considered unreliable.
Conclusions:
- The original conclusions drawn from the study are invalidated.
- The retraction highlights the importance of data integrity in scientific research.
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