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Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

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Conductive Tough Hydrogel for Bioapplications.

Mohammad Javadi¹, Qi Gu^1,2, Sina Naficy³

¹ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, University of Wollongong, Wollongong, New South Wales, 2522, Australia.

Macromolecular Bioscience

|December 14, 2017

Summary

Researchers developed a new biocompatible, conductive, and tough hydrogel using polyurethane (PU), PEDOT:PSS, and liquid crystal graphene oxide (LCGO). This advanced material enhances neural stem cell (NSC) growth and differentiation, showing promise for neural tissue engineering.

Keywords:

PEDOT:PSS conductive hydrogel graphene neural stem cells polyurethane

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Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Published on: May 5, 2023

Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Biocompatible conductive tough hydrogels are emerging advanced materials.
Combining toughness, conductivity, and biocompatibility is crucial for advanced applications.

Purpose of the Study:

To report a simple method for creating a self-assembled tough, elastomeric, biocompatible, and conductive hydrogel.
To investigate the properties and potential applications of the developed hydrogel.

Main Methods:

Synthesized a hydrogel composite using polyether-based polyurethane (PU), PEDOT:PSS, and liquid crystal graphene oxide (LCGO).
Characterized the mechanical and electrical properties of the polyurethane hybrid composite (PUHC).
Assessed the biocompatibility and effect on human neural stem cell (NSC) growth, differentiation, and neuritogenesis.

Main Results:

The PUHC exhibited significantly enhanced electrical conductivity (10×), tensile modulus (>1.6×), and yield strength (>1.56×) compared to controls.
The PUHC demonstrated excellent biocompatibility, supporting human NSC growth and differentiation into neurons and neuroglia.
Electrical stimulation of the PUHC further enhanced NSC differentiation and neuritogenesis.

Conclusions:

A novel biocompatible conductive tough hydrogel (PUHC) was successfully developed.
The PUHC shows significant improvements in mechanical and electrical properties.
The material effectively supports neural stem cell differentiation, indicating potential for neural tissue engineering and regenerative medicine.