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Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically

T Kuusi1, M S Nieminen, C Ehnholm

  • 1First Department of Medicine, University of Helsinki, Finland.

Arteriosclerosis (Dallas, Tex.)
|March 1, 1989
PubMed

Insights

Genetic variations in apolipoprotein E (apo E) are linked to coronary artery disease (CAD). The study found a higher frequency of the apo E epsilon 4 allele in Finnish men with CAD, suggesting a genetic predisposition.

Area of Science:

  • Cardiovascular Genetics
  • Human Genetics

Background:

  • Genetic polymorphism of apolipoprotein E (apo E) is implicated in coronary artery disease (CAD).
  • Previous research suggests a link between apo E genotypes and CAD risk.

Purpose of the Study:

  • To determine the apolipoprotein E (apo E) phenotype distribution in Finnish men with confirmed coronary artery disease (CAD).
  • To investigate the association between apo E genotype and CAD risk in a Finnish population.

Main Methods:

  • Analysis of apo E phenotype in 91 Finnish men diagnosed with coronary artery disease (CAD).
  • Comparison of apo E phenotype distribution in patients versus the general Finnish population.
  • Assessment of serum lipoproteins and postheparin plasma lipase activities across different apo E phenotypes.

Main Results:

  • The apo E phenotype distribution in CAD patients was significantly different from the general Finnish population (p < 0.05).
  • The frequency of the apo E epsilon 4 allele was 0.324 in the patient group, 1.4-fold higher than in the normal Finnish population.
  • This epsilon 4 allele frequency was twice as high as observed in other Caucasian populations.
  • No significant variations in serum lipoproteins or postheparin plasma lipase activities were found based on apo E phenotype.

Conclusions:

  • The findings confirm and extend previous data on the association between the apo E epsilon 4 allele and coronary artery disease (CAD) risk.
  • The high frequency of the apo E epsilon 4 allele in the Finnish population may contribute to their increased susceptibility to CAD.

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