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Updated: Feb 17, 2026
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
Published on: November 17, 2023
Comparing different nanofat procedures on scars: role of the stromal vascular fraction and its clinical implications
Pietro Gentile1, Maria Giovanna Scioli2, Alessandra Bielli2
1Plastic & Reconstructive Surgery, Department of Biomedicine & Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Aim:
Recently, a new fat grafting technique termed 'nanofat grafting' was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield.
Methods:
Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure.
Results:
Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments.
Conclusion:
This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.
